Profhilo vs Rejuran: Which Skin Booster Should You Choose?

Choosing between Profhilo and Rejuran mostly comes down to your main skin concern. Profhilo is a high-concentration hyaluronic acid product that spreads through the skin to improve hydration, laxity and a crepey texture, and it is usually given in just two sessions. Rejuran is a polynucleotide (PN) booster aimed more at skin repair, resilience, fine texture and sensitive or damaged skin, and it is typically given as a series of three or more sessions. Both are well-established skin boosters, and in some cases doctors use them together.

Below, we compare how each works, what results to expect, how the treatment feels and which types of skin tend to benefit most.

What Profhilo Is

Profhilo contains a very high concentration of hyaluronic acid made using a heat-based stabilization process instead of the chemical cross-linking found in many fillers. The result is a fluid gel that disperses widely after injection rather than staying in one spot.

It is usually injected at a small number of standard points on each side of the face, often five, using a technique sometimes called "BAP" (bio-aesthetic points). The product then spreads across the area.

Profhilo is described as a "bio-remodeling" treatment. Beyond hydration, it is thought to support the skin's own collagen and elastin over time, giving a firmer, smoother look without changing facial shape.

What Rejuran Is

Rejuran is a Korean product based on polynucleotides, purified DNA fragments derived from salmon. Several versions exist, including formulations designed for general skin quality, the delicate eye area and scarring.

It is usually injected as many small blebs across the treatment area, either by hand or with an injection device. The polynucleotides are believed to support tissue repair, calm inflammation and improve the environment in which collagen is produced. Patients often describe their skin feeling thicker, calmer and more resilient after a course.

Comparing Results

Profhilo tends to suit

• Mild to moderate skin laxity, where skin looks slightly loose or crepey.
• Dehydrated, dull skin that lacks bounce.
• Neck, lower face and jawline skin quality.
• People who want fewer injection points and a shorter course.

Rejuran tends to suit

• Thin, sensitive or reactive skin.
• Fine textural irregularities and enlarged-looking pores.
• Fine lines, including under-eye crepiness with the eye-specific formulation.
• Skin recovering from lasers, procedures or long-term irritation.
• Shallow acne scarring, usually as part of a combined plan.

In short, Profhilo is often chosen for hydration and a "lifted" quality, while Rejuran is chosen for repair and refinement. These are generalizations, and individual responses vary.

Treatment Experience and Downtime

Profhilo

With only a few injection points per side, sessions are quick. You may see small raised bumps at each point for several hours up to about a day, along with occasional bruising. Most people return to normal activities quickly.

Rejuran

Because it involves many small injections and the product itself can sting, Rejuran is often considered one of the more uncomfortable skin boosters. Numbing cream is usually applied first. Small bumps across the treated area are common for one to three days, and pinpoint bruising can appear.

For travelers, this difference matters: Profhilo bumps usually settle faster, while Rejuran may require a few quiet days if you are concerned about appearance.

Number of sessions and longevity

• Profhilo: commonly two sessions about four weeks apart, then maintenance roughly every six months, depending on the person.
• Rejuran: commonly three or four sessions spaced two to four weeks apart, then maintenance every several months.

Both build results gradually. Profhilo hydration may be noticeable within a couple of weeks, while Rejuran's improvement in texture and resilience usually becomes clearer after the second or third session. Results last several months to around a year, depending on age, skin condition and lifestyle.

Safety Considerations

Both are generally considered safe when given by trained practitioners. Shared risks include bruising, swelling, temporary lumps, infection and, rarely, vascular problems. Some specific points:

• Profhilo is HA-based and can generally be dissolved with an enzyme if needed.
• Rejuran is derived from fish DNA, so a fish allergy should be discussed with your doctor beforehand.
• Neither is generally recommended during pregnancy or breastfeeding.
• Treatment should be postponed if you have an active infection, cold sore or acne flare in the area.

Can You Combine Profhilo and Rejuran?

Yes, and some doctors do. A combined plan might use Rejuran to improve skin resilience and texture and Profhilo to add hydration and support laxity. They may be scheduled on separate days or in alternating sessions. The benefit of combination depends on your skin, and it adds cost and time, so it should be a considered decision rather than an automatic upgrade.

How to Decide

Ask yourself which of these best describes your main concern:

1. "My skin looks dry, tired and a little loose." Profhilo is often a natural first consideration.
2. "My skin is thin, sensitive or has uneven texture and fine lines." Rejuran is often the first consideration.
3. "I want my under-eye skin to look less crepey." An eye-specific polynucleotide product is often discussed, though suitability depends on the anatomy of the area.
4. "I have only one session available during my trip." Discuss which product gives a meaningful result from a single treatment, and how to continue at home.

Frequently asked questions

Which one hurts more?

Most people find Rejuran more uncomfortable because of the number of injections and the nature of the product. Numbing cream helps. Profhilo usually involves fewer, quicker injections.

Will either change the shape of my face?

No. Both are designed to improve skin quality rather than add volume or change contours. For structural changes, fillers or other treatments are more relevant.

Can I have them before a flight?

Many people fly within a day or two without problems, but it is sensible to allow time for swelling and bumps to settle and to ask your doctor about timing.

Which lasts longer?

Both last several months to about a year after a full course, with maintenance needed. Differences between individuals are often larger than differences between the two products.

Speak with a Dermatologist

Profhilo and Rejuran are both useful tools, but they solve slightly different problems. A qualified dermatologist can examine your skin, ask about your goals and schedule, and recommend one, the other or a combination. This guide is meant to help you ask better questions, not to replace a personal consultation.